胎球蛋白B与动脉粥样硬化研究关系的进展

Research Progress of Relationship between Fetuin B and Atherosclerosis

动脉粥样硬化(Atherosclerosis, As)是多种心血管疾病的病理学基础,但其复杂的病理生理机制至今仍未充分明确。同时肝脏因子与心血管疾病的发生、发展存在着某种相关性,此类因子中即包括胎球蛋白B (Fetuin B)。胎球蛋白B是一种近几年发现的由肝脏分泌的糖蛋白,在炎症、组织钙化、糖脂代谢、生殖与肿瘤等方面发挥着广泛的生理病理活性。目前有研究表明胎球蛋白B可增加心血管事件的风险,但其作用机制尚不明确,因此,本文的目的是分析胎球蛋白B和As对于机体病理生理的调控效应,为此类疾病的防治提供新思路与新方案。

Atherosclerosis (As) is the pathological basis of a variety of cardiovascular diseases (CVD). There are complex pathophysiological mechanisms of atherosclerosis, but it has not been fully defined. At the same time, there is a certain correlation between liver factors and the occurrence and development of cardiovascular diseases, including fetuin B. Fetuin B is a glycoprotein secreted by the liver, which has been found in recent years. It plays a wide range of physiological and pathological activities in inflammation, tissue calcification, glucose and lipid metabolism, reproduction and tumor. At present, studies have shown that fetuin B can increase the risk of cardiovascular events, but its mechanism is not clear. Therefore, the purpose of this study is to analyze the regulatory effect of fetuin B and as on the pathophysiology of the body, and to provide new ideas and new programs for the further prevention and treatment of such diseases.