原发性高血压患者内皮祖细胞功能变化及与FMD的相关性

Change of the Functional Activity of Endothelial Progenitor Cells and Their Correlation with FMD in Primary Hypertension Patients

目的:探究原发性高血压患者内皮祖细胞(endothelial progenitor cells, EPCs)功能的变化及与内皮依赖血管舒张功能(FMD)的相关性。方法:实验组为15例原发性高血压3级患者和对照组为同期健康体检者20人。取研究对象的外周血20 ml,CCK8法和Transwell小室检测EPCs功能(增殖、迁移)。结果:与对照组比较,高血压患者的EPCs的迁移、增殖功能明显较低(p 【0.05);原发性高血压患者FMD明显低于正常对照组(p 【0.05),同时我们发现循环内皮祖细胞迁移和增殖分别与FMD强正相关(分别为r = 0.56,0.41,p 【0.05)。结论:原发性高血压EPC的功能下降,可能与FMD损伤有关。

Objective: To investigate change of the function of endothelial progenitor cells (EPCs) and their correlation with flow-mediated dilation (FMD) in patients with primary hypertension. Methods: 15 patients with grade 3 primary hypertension as experimental group and 20 healthy persons as control group. The function (proliferation and migration) of EPCs were analyzed by CCK8 and Transwell chambers. Results: Compared with the control group, the migration and proliferation function of EPCs in primary hypertension patients were significantly lower (p <0.05). FMD in primary hypertension group was lower than that in healthy group (p <0.05), and we found a strong unilabiate correlation between the migratory and proliferatory of circulating EPCs and FMD (r = 0.56, 0.41, p <0.05, respectively). Conclusion: The function of EPCs decreased may be related with FMD injury.