NLPR3炎症小体在心肌纤维化中的作用的研究

The Role and Progress of NLPR3 Inflammatory in Myocardial Fibrosis

NLRP3炎症小体是一种多蛋白寡聚体复合物,通过产生IL-1和IL-18来激活炎症反应。该复合物在创伤早期有助于愈合,但在持续激活后会导致不可逆的心室重构以及心肌纤维化。本文针对NLRP3炎症复合体在多种疾病所致心肌纤维化中所起的作用,以及目前发现可能存在的一些信号机制进行了综述。

NLRP3 inflammatory is a multiprotein oligomer complex that activates inflammation by producing IL-1 receptors and IL-18, which not only contributes to wound healing, but also leads to irreversible ventricular remodeling and myocardial fibrosis after continuous activation. This article reviews the factors that cause the initiation and activation of NLRP3 inflammatory complex, and how the activated inflammatory complex promotes the fibrosis process and other pathophysiological processes of cardiovascular disease.