摘要
肌腱损伤是运动医学中的常见问题。巨噬细胞在肌腱愈合过程中的作用是一个新兴的领域。作为重要的炎症细胞之一,巨噬细胞根据不同的表型具有不同的功能。M1型巨噬细胞具有吞噬和促炎症功能,M2型巨噬细胞与炎症和组织沉积的消退有关。以往的研究认为炎症细胞在肌腱的愈合过程发挥的作用很小,但现今巨噬细胞已经被发现在肌腱愈合过程中发挥重要的调节作用。其可通过释放炎性因子等方式干扰肌腱组织的愈合及修复能力。然而目前对于巨噬细胞在肌腱愈合中作用的了解仍非常有限,因此探讨巨噬细胞在肌腱愈合过程中的作用至关重要,并可为以后促进肌腱修复的研究及治疗提供新的思路。
Tendon injuries are common problems in sports medicine. The role of macrophages in tendon healing is a new area. Macrophages are important inflammatory cells, and their function depends on their functional phenotype. M1 macrophages have phagocytic and pro-inflammatory functions, and M2 macrophages are related to the regression of inflammation and tissue deposition. Previous studies have suggested that inflammatory cells play a small role in tendon healing, but macrophages have been found to play an important regulatory role in tendon healing. It can interfere with the healing and repairability of tendon tissue by releasing inflammatory factors. However, the understanding of the role of macrophages in tendon healing is still very limited, so it is very important to explore the role of macrophages in tendon healing and can provide new ideas for the research and treatment of tendon repair in the future.
出处
《临床医学进展》
2022年第1期311-318,共8页
Advances in Clinical Medicine
