肾性贫血和铁代谢的研究进展

Research Progress of Renal Anemia and Iron Metabolism

肾性贫血是慢性肾功能不全发展到终末期肾脏病常见的并发症之一,会导致患者机体功能受损和生活质量下降,同时增加慢性肾脏病(chronic kidney disease, CKD)患者的死亡风险。铁代谢平衡对维持机体正常生理功能至关重要,铁稳态失衡是导致CKD患者绝对或功能性缺铁性贫血的一个重要原因。本文将就近些年来肾性贫血的诊断与治疗目标、铁代谢、铁调素和肾性贫血药物治疗的研究进展作一综述。

Renal anemia is one of the common complications of chronic renal insufficiency to end-stage renal disease, which will lead to impaired body function and decreased quality of life, and increase the risk of death in patients with chronic kidney disease. Iron metabolism balance is crucial to maintain normal physiological functions of the body, and iron homeostasis imbalance is an important cause of absolute or functional iron deficiency anemia in patients with CKD. This article will review the diagnosis and treatment of renal anemia, iron metabolism, hepcidin and drug therapy of renal anemia in recent years.