摘要
p53正向细胞凋亡调控因子(p53 up-regulated modulator of apoptosis, PUMA)在许多疾病的发生发展中发挥着至关重要的作用,其调控机制主要为转录水平的调控(p53依赖/非依赖途径)及翻译后磷酸化调控机制,相关microRNA-PUMA信号通路的发现,不仅为肿瘤性疾病的治疗提供了新依据,也为许多非肿瘤性疾病的治疗提供了新思路,如老年性急性心肌梗死、心脏瓣膜病、神经元退行性变、血脑屏障等疾病近年来有了新的突破,甚至有望成为疾病新的预测分子。本文主要从microRNA-PUMA相关通路的发现就近年来在非肿瘤性疾病中的研究作一综述。
p53 up-regulated modulator of apoptosis (PUMA) plays an important role in the development of many diseases. Its regulatory mechanisms include transcriptional regulation (p53-dependent/ non-dependent pathway) and post-translational phosphorylation. The discovery of related microRNA-PUMa signaling pathway not only provides a new basis for the treatment of neoplastic diseases, but also provides a new idea for the treatment of many non-neoplastic diseases: for example, senile acute myocardial infarction, heart valvular disease, neuronal degeneration, blood-brain barrier and other diseases have made new breakthroughs in recent years, and are even expected to become new predictive molecules of diseases. In this paper, the findings of microRNA-PUMA related pathways in non-neoplastic diseases in recent years are reviewed.
出处
《临床医学进展》
2022年第1期709-715,共7页
Advances in Clinical Medicine
