LncRNAs在糖尿病肾病中的功能及意义研究进展

Progress in the Function and Significance of LncRNAs in Diabetic Nephropathy

糖尿病肾病是糖尿病重要的微血管并发症,引起持续进展的慢性肾脏损害,导致肾功能衰竭。糖尿病肾病作为慢性肾病患者主要病因及死亡原因,极大地加重了全球健康及经济负担。糖尿病肾病发病机制较为复杂,现有治疗方案效果有限,亟待进一步探索发病机制,以更好地预防、治疗、管理糖尿病肾病。长链非编码RNA参与了许多生理过程,如细胞周期调节、细胞凋亡和存活、肿瘤迁移和代谢等。某些LncRNAs在糖尿病肾病发病机制中发挥重要作用。本文综述了参与糖尿病肾病发病机制、作为生物标志物或在临床应用中作为治疗靶点的LncRNAs。

Diabetic nephropathy (DN) is a major microvascular complication of diabetes mellitus, leading to gradual progress in chronic deterioration of renal function, eventually resulting in the occurrence of kidney failure. DN is the major cause of the high morbidity and mortality of chronic kidney disease (CKD), which significantly aggravates the healthy and economic burden globally. Therefore, it is important to explore the underlying mechanism for prevention and management of DN due to the complicated pathogenesis and limited therapy. Long noncoding RNA (LncRNA), a novel target, is involved in many physiological processes, such as cell cycle regulation, apoptosis, cell survival, tumor migration and metabolism. Furthermore, evidence suggests that LncRNAs play a vital role in DN pathogenesis. This review summarizes LncRNAs, which are involved in the pathogenesis of DN, and used as biomarkers or therapeutic targets of DN in clinical practice.