miRNA与动脉粥样硬化相关性研究进展

Research Progress of Correlation between miRNA and Atherosclerosis

微小核糖核酸(miRNA, MicroRNA)是一类非编码单链RNA分子,越来越多的研究证据表明miRNA能够影响动脉粥样硬化(atherosclerosis, AS)的发生发展,并为AS的诊断及治疗提供了靶点。AS发生发展主要和内皮细胞、平滑肌细胞、巨噬细胞密切相关。本文就miRNA通过作用于平滑肌细胞、巨噬细胞、内皮细胞影响AS的相关研究进展进行综述。

miRNA is a kind of non-coding single stranded RNA molecules. In recent years, more and more studies have shown that miRNA can affect the occurrence and development of atherosclerosis, and supply a target for the diagnosis and treatment of AS. The development of AS is closely related to endothelial cells, smooth muscle cells and macrophages. This paper reviews the research progress on the impacts of miRNA on AS by acting on smooth muscle cells, macrophages and endothelial cells.