三级淋巴结构与肿瘤相关巨噬细胞在肝癌中的研究进展

Research Progress of Tertiary Lymphoid Structure and Tumor-Associated Macrophages in Hepatocellular Carcinoma

三级淋巴结构(TLS)是位于非典型淋巴器官部位的异位淋巴组织,以应对慢性和进行性炎症过程,如感染、移植物排斥反应、自身免疫性疾病和癌症等。在炎症驱动型癌症肝细胞肝癌(HCC)中发现了成熟程度不同的TLS。其由各种类型的免疫细胞组成,包括树突状细胞和抗原特异性B淋巴细胞和T淋巴细胞,以及巨噬细胞等,它们共同驱动针对肿瘤发展和进展的免疫反应。本篇综述旨在总结迄今为止TLS在HCC预后方面的矛盾的研究现状,试分析这种差异性结果出现的原因,以及肿瘤相关巨噬细胞(TAMs)在其中扮演的角色,为进一步的研究提供新的视角。

Tertiary lymphoid structure (TLS) is the ectopic lymphoid tissue located in atypical lymphoid organs to deal with chronic and progressive inflammatory processes such as infection, graft rejection, autoimmune diseases and cancer. TLS with varying degrees of maturity has been found in inflammation-driven cancer hepatocellular carcinoma (HCC). It is composed of various types of immune cells, including dendritic cells and antigen-specific B lymphocytes and T lymphocytes, as well as macrophages, etc., which together drive the immune response against tumor development and progression. This review aims to summarize the contradictory research status of TLS in the prognosis of HCC so far, and tries to analyze the reasons for the emergence of such differential results, and the role of tumor-associated macrophages (TAMs) in it, so as to provide a new perspective for further research.