胎儿炎症反应综合征的产前诊断

Prenatal Diagnosis of Fetal Inflammatory Response Syndrome

胎儿炎症反应综合征(fetal inflammatory response syndrome, FIRS)是指在感染或缺氧等刺激下胎儿体内大量炎性因子释放的一种亚临床状态,与新生儿不良预后相关,靠脐血或胎盘组织检查可确诊。随着对FIRS对新生儿损伤影响及无创诊断方法的研究,使超声探查胎儿器官改变(如心脏、肾脏、肾上腺及胸腺)诊断FIRS成为可能。

Fetal inflammatory response syndrome (FIRS) is a sub-clinical state of a massive releasing of inflammatory factors in the fetus under the infection or hypoxia. It is related to the adverse outcomes of neonates and is usually diagnosed by umbilical cord blood or placenta histological examination. With the recognition of the impact of FIRS on neonates and the development of non-invasive diagnostic methods, it is possible to diagnose FIRS by detecting fetal organ changes (heart, kidney, adrenal gland and thymus) on ultrasound.