血管内皮生长因子、白介素-6、同型半胱氨酸在肝硬化及食管胃静脉曲张中的研究进展

Advances in Vascular Endothelial Growth Factor, Interleukin-6 and Homocysteine in Liver Cirrhosis and Gastroesophageal Varices

肝硬化是我国常见的慢性疾病,肝硬化患者常常合并门静脉高压,其最主要表现为食管胃静脉曲张(gastroesophageal varices, GOV),严重威胁患者健康。血管内皮生长因子(vascular endothelial growth factor, VEGF)、白介素-6 (interleukin 6)、同型半胱氨酸(homocysteine, HCY)表达升高与肝硬化患者GOV形成及严重程度密切相关,预测作为评估的新指标,对预后及病情评估有一定价值。本文就VEGF、IL-6、HCY在肝硬化合并胃食管静脉曲张的作用机制、临床评估及未来诊疗展望进行综述。

Liver cirrhosis is a common chronic disease in my country, and patients with liver cirrhosis are often associated with portal hypertension, the main manifestation of which is gastroesophageal varices (GOV), which seriously threatens the health of patients. Elevated expressions of vascular endothelial growth factor (VEGF), interleukin-6 (interleukin 6) and homocysteine (HCY) are closely related to the formation and severity of GOV in patients with liver cirrhosis. The new index has certain value for prognosis and disease assessment. This article reviews the mechanism of action of VEGF, IL-6 and HCY in liver cirrhosis complicated with gastroesophageal varices, clinical evaluation and future diagnosis and treatment prospects.