循环肿瘤细胞在结直肠癌中的应用

Application of Circulating Tumor Cells in Colorectal Cancer

具有高特异性和敏感性的新的诊断和预后生物标志物是目前管理结直肠癌患者的一个重要的需求。循环肿瘤细胞(Circulating tumor cells, CTC)被认为是肿瘤复发的原因,得益于分子生物学技术的发展,其正在逐步应用于恶性肿瘤的临床诊疗中。它具有微创、可重复的优点,可在结肠直肠癌患者的筛查和诊断、预测复发和转移、监测微小残留病和化疗耐药等方面发挥重要作用。尽管有这些优势,但它并没有包括在临床指南中,仍有一些实际问题需要解决。该文的目的是对已进行的临床试验进行总结,进一步理解其在结直肠癌患者管理中的作用。

New diagnostic and prognostic biomarkers with high specificity and sensitivity are currently an important need in the management of patients with colorectal cancer. Circulating tumor cells (CTC) are considered to be the cause of tumor recurrence. Thanks to the development of molecular biology technology, CTC has been gradually applied in the clinical diagnosis and treatment of malignant tumors. It has the advantages of minimally invasive and repeatable, and can play an important role in screening and diagnosis of colorectal cancer patients, predicting recurrence and metastasis, monitoring minimal residual disease and chemotherapy resistance. Despite these advantages, they are not included in clinical guidelines and there are practical issues that need to be addressed. The purpose of this article is to summarize the clinical trials that have been conducted and to further understand its role in the management of patients with colorectal cancer.