NETs在痛风中的研究进展

Research Progress of NETs in Gout

痛风是一种常见的具有自限性的自身炎症性疾病,急性发作时以关节的红肿热痛为主。近年来,研究发现中性粒细胞胞外诱捕网(neutrophils extracellular traps, NETs)可能在痛风的炎症机制起着重要作用,一方面有促进痛风性关节炎的急性发作作用,另一方面有促进痛风炎症缓解的作用。血小板与机体的炎症有着密切关系,同时活化的血小板具有促进NETs的形成作用。本篇综述将概述痛风、NETs及血小板相互之间的影响。

Gout is a common self-limited inflammatory disease. The acute attack is mainly caused by redness, swelling, heat and pain of joints. In recent years, it has been found that neutrophils extracellular traps (NETs) may play an important role in the inflammatory mechanism of gout. On the one hand, they can promote the acute attack of gout arthritis, and on the other hand, they can promote the inflammatory relief of gout. Platelets are closely related to inflammation, and activated platelets can promote the formation of NETs. This review will provide an overview of the interactions between gout, NETs, and platelets.