半乳糖凝集素-3在软骨细胞凋亡过程中作用的研究进展

Research Progress on the Role of Galectin-3 in Chondrocyte Apoptosis

半乳糖凝集素-3 (Galectin-3)作为凝集素超家族中的一员,与其它凝集素一样,由一个糖基与非糖基配体结合而成,可在全身组织中表达并与诸多疾病具有相关性,目前已得到广泛重视。近年来发现初级纤毛是一种感觉相关的细胞器,其在软骨细胞中能敏锐感知机械载荷变化,从而调控软骨细胞新陈代谢,但其在软骨细胞中的形成及功能与Galectin-3密切相关。髋关节发育不良(developmental dysplasia of the hip, DDH)与软骨异常细胞凋亡相关。本文就Galectin-3在软骨细胞凋亡过程中的作用进行综述。

As a member of the lectin superfamily, galectin-3, like other lectins, is composed of a glycosyl and non-glycosyl ligand. Galectin-3 can be expressed in whole body tissues and is associated with many diseases. In recent years, it has been found that primary cilia is a sensory-related organelle, which can acutely sense the changes of mechanical load in chondrocytes, thus regulating the metabolism of chondrocytes, but its formation and function in chondrocytes are closely related to galectin-3. Developmental dysplasia of the hip is associated with abnormal chondrocyte apoptosis. This article reviews the role of galectin-3 in the process of chondrocyte apoptosis.