DACH1在多种肿瘤发生中的作用机制研究进展

Research Progress on the Mechanism of Action of DACH1 in Various Tumorigenesis

肿瘤一直以来都是全世界医学研究的热门课题。近年来,研究发现细胞命运决定因子DACH1在人类多种肿瘤细胞中的表达与肿瘤的发展关系密切。然而DACH1在肿瘤中确切的作用和机制还没有形成统一的认识。本文对DACH1的来源分布、结构特点、生物学功能以及在多种肿瘤细胞中的发生发展机制进行了综述,皆在探索DACH1在肿瘤发生发展中的抑制作用。

Tumor has always been a hot topic in medical research all over the world. In recent years, it has been found that the expression of cell fate determinant DACH1 in a variety of human tumor cells is closely related to the development of tumor. However, the exact role and mechanism of DACH1 in tumor have not yet formed a unified understanding. In this paper, the origin, distribution, structural characteristics, biological function and the mechanism of occurrence and development of DACH1 in a variety of tumor cells were reviewed, all of which were to explore the inhibitory effect of DACH1 on tumorigenesis and development.