肺部微生物在早产儿支气管肺发育不良中的作用研究进展

Lung Microbiome and Bronchopulmonary Dysplasia in Preterm Infants

支气管肺发育不良(Bronchopulmonary dysplasia BPD)是早产儿严重并发症之一,其病因、发病机制尚不明确。近年来,随着微生物测序技术和生态学理论的发展,肺部微生物受到研究者们的关注,并被发现可能与BPD发生发展相关。本文就近期关于生命早期肺部微生物定植的相关证据及其在早产儿支气管肺发育不良中作用的相关研究进展进行综述及展望。

Bronchopulmonary dysplasia (BPD) is one of the intractable complications in preterm infants, while its etiology and pathogenesis are still unclear. Recently, the association between lung microbiome and BPD has been widely studied, thanks to the advancements in sequencing technology and theoretical microbial ecology. This review summarizes the latest evidence on the microorganism colonization in the respiratory tract in early life and the correlation between lung microbiome and BPD.