维生素D与儿童肺炎支原体肺炎的相关性研究进展

Research Progress on the Relationship between Vitamin D and Mycoplasma Pneumoniae Pneumonia in Children

肺炎支原体肺炎是儿科的常见病和多发病,其发病机制可能与肺炎支原体直接黏附和感染后机体免疫功能紊乱、炎症反应有关,并可引起多种肺内外并发症。随着肺炎支原体肺炎发病率逐年升高,耐药现象越来越明显,且难治性肺炎支原体肺炎(refractory Mycoplasma pneumoniae pneumonia, RMPP)及重症肺炎支原体肺炎(severe Mycoplasma pneumonia pneumonia, SMPP)的报道不断增加,对其早期识别和探索有效的防治措施对预后具有重要意义。近年来,维生素D的免疫调节作用得到广泛关注,维生素D缺乏或不足在儿童中呈高发态势,现就维生素D与儿童肺炎支原体肺炎的相关研究进行归纳、总结。

Mycoplasma pneumoniae pneumonia is a common and frequently-occurring disease in pediatrics. Its pathogenesis may be related to the direct adhesion of Mycoplasma pneumoniae, immune dysfunction and inflammatory response after infection, which can cause a variety of internal and external complications. With the increasing incidence of Mycoplasma pneumoniae pneumonia, the phenomenon of drug resistance is becoming more and more obvious, and refractory Mycoplasma pneumoniae pneumonia (RMPP) and severe Mycoplasma pneumoniae pneumonia (SMPP) are increasing year by year. It seriously damages the physical and mental health of children. Early identification and exploration of effective preventive measures are of great significance to prognosis. In recent years, the nutritional status of vitamin D and its immune regulation in children have received great attention. Vitamin D deficiency or insufficiency is common in children. The related research on vitamin D and MPP in children are summarized.