斯钙素2的相关研究进展

Research Progress of Stanniocalcin 2

斯钙素2是一种最初在鱼类中发现的分泌型糖蛋白激素,被证实有调节钙磷的作用。近年来研究发现,STC2在哺乳动物及人类的多种组织器官中存在,并且与糖脂代谢、生长发育、摄食、糖尿病等生理病理过程关系密切。大量研究证实STC2参与了肿瘤的发生发展,是一种新的潜在的肿瘤标记生物分子。本文主要综述STC2的分子结构、分布、功能及其与不同疾病的关系。

Stanniocalcin 2 (STC2), a secreted glycoprotein hormone originally discovered in fish, has been shown to involve in calcium and phosphate regulation. In recent years, studies have found that STC2 protein exists in various tissues of mammals and humans, which is closely related to physiological and pathological processes such as glucose and lipid metabolism, growth and development, feeding, and diabetes. Additionally, STC2 plays a role in the occurrence and development of tumors and is considered to be a new potential tumor marker. Therefore, this paper mainly reviews the molecular structure, distribution, function of STC2 and its relationship with different diseases.