闭锁小带蛋白-1与消化系统疾病关系的研究

Study on the Relationship between Zonula Occludens-1 and Digestive System Diseases

消化系统通过消化吸收和物质转换等功能为全身代谢提供能量,维持生命所需。在消化系统黏膜上皮或内皮之间存在一种物理屏障,这种物理屏障可阻隔有害物质侵入消化道黏膜,减少消化系统疾病的发生。其结构主要包括紧密连接、缝隙连接、黏附连接和桥粒,其中紧密连接在维持黏膜功能稳定性中起主要作用。病原微生物移位、内毒素和大分子物质侵袭以及药物等因素最终通过破坏相邻两细胞间紧密连接结构和功能而导致消化系统疾病。紧密连接是一种结构复合体,包括胞膜蛋白和胞质蛋白,近年来关于紧密连接相关蛋白与消化系统疾病关系的研究颇多,本文主要就紧密连接中胞内蛋白闭锁小带蛋白-1 (zonula occludens-1, ZO-1)与消化系统疾病关系进行阐述。

The digestive system provides energy for systemic metabolism and maintains life needs through digestion, absorption, material conversion and other functions. There is a physical barrier between the mucosal epithelium or endothelium of the digestive system. This physical barrier can prevent harmful substances from invading the digestive tract mucosa and reduce the occurrence of digestive system diseases. Its structure mainly includes tight junction, gap junction, adhesive junction and desmosomes. Tight junction plays a major role in maintaining the functional stability of mucosa. The translocation of pathogenic microorganisms, the invasion of endotoxin and macromolecular substances and drugs eventually lead to digestive system diseases by destroying the tight junction structure and function between two adjacent cells. Tight junction is a structural complex, including membrane proteins and cytoplasmic proteins. In recent years, there have been many studies on the relationship between tight junction related proteins and digestive system diseases. This paper mainly expounds the relationship between zonula occludens-1 (ZO-1) in tight junction and digestive system diseases.