摘要
完整的补体系统可改善胎盘的发育和功能,对维持宿主防御和胎儿存活至关重要。补体调节在妊娠早期发挥重要作用,一定程度的补体激活保证妊娠的正常发生。妊娠期间,妊娠过程靠母体的免疫抑制状态保证,补体激活的适当抑制则成为了妊娠所必需。正常妊娠的胎盘滋养层细胞在整个妊娠期高表达补体调节蛋白衰变加速因子(decay-accelerating factor, DAF, CD55)、膜辅助蛋白(membrane cofactor protein, MCP)和CD59,可阻止母体补体的过度激活对胚胎的损伤。部分研究显示,CD55表达受损可能会产生免疫异常环境,破坏胚胎植入和妊娠早期发育。本次我们旨在分析补体系统中的补体调节蛋白CD55与复发性流产之间的潜在关联。
A complete complement system can improve placental development and function, and is essential for maintaining host defense and fetal survival. Complement regulation plays an important role in the early pregnancy, and a certain degree of complement activation ensures the normal pregnancy. During pregnancy, it is guaranteed by the maternal immunosuppression state, and the proper inhibition of complement activation becomes necessary for pregnancy. The placental trophoblast cells in normal pregnancy highly express decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP) and CD59, which can prevent the overactivation of maternal complement. Some studies have shown that impaired CD55 expression may produce an abnormal immune environment that disrupts embryo implantation and early pregnancy development. This time we aimed to analyze the potential association between the complement regulatory protein CD55 in the complement system and recurrent abortion.
出处
《临床医学进展》
2022年第4期3454-3459,共6页
Advances in Clinical Medicine
