成纤维细胞在皮肤老化中的作用机制研究进展

Research Progress on the Mechanism of Fibroblasts in Skin Aging

皮肤是人体最大的器官,随着人们年龄的增长,不仅会像其他器官一样出现功能减退,引起各种疾病,而且会逐渐出现皮肤老化的状态。皮肤老化反映在的细胞水平即是细胞老化。而皮下成纤维细胞则是真皮中最主要的细胞成份之一,当皮肤衰老时,成纤维细胞则有数量下降、形状变化,以及分泌与合成功能下降的现象。深入研究成纤维细胞在皮肤老化中的作用机理,主要涉及AGES、ROS-MMP、抑癌基因激活、miRNAs、LncRNA TERRA等,为研究防止和推迟皮肤衰老提出了全新的思想和指导意义。本文将就成纤维细胞在皮肤衰老中的作用机理做出系统综述。

The skin is the largest organ of the human body. As people age, not only will the function decline like other organs, causing various diseases, but also the state of skin aging will gradually appear. The cellular level reflected in skin aging is cellular aging. The subcutaneous fibroblasts are one of the most important cell components in the dermis. When the skin ages, the fibroblasts will decrease in number, change in shape, and decrease in secretion and synthesis functions. In-depth study of the mechanism of fibroblasts in skin aging, mainly involving AGES, ROS-MMP, tumor suppressor gene activation, miRNAs, LncRNA TERRA, etc., puts forward new ideas and guiding significance for the study of preventing and delaying skin aging. This article will provide a systematic review on the mechanism of fibroblasts in skin aging.