颅脑损伤的炎症反应

The Inflammatory Response to Craniocerebral Injury

颅脑损伤是一个难以预料、有多种因素参加的疾病发展过程,其中对脑组织的损伤包括原发性和继发性的损伤。原发性的颅脑损伤包括外力对颅内结构的物理性破坏,是对脑实质和脑血管的直接性损伤,如血肿、挫伤等,其损伤程度及部位无法被临床医生控制及预料病情。但其导致的相关生化途径的激活及作用细胞可被控制及预防病情发展。继发性颅脑损伤可进一步使脑损伤加重,主要是通过兴奋性神经递质活性增强、炎症细胞因子释放和活性氧(ROS)的产生导致的。因此控制炎症反应对脑损伤的病情控制及预后有重要意义,希望能够更好地了解脑损伤的炎症反应的进展,增加更有效的脑损伤治疗方法。

Craniocerebral injury is an unpredictable and multifactorial process of disease development, in which brain tissue damage includes primary and secondary damage. Primary craniocerebral injury includes physical destruction of intracranial structure by external forces, and is direct injury to brain parenchyma and cerebrovascular, such as hematoma and contusion. The degree and location of injury cannot be controlled and predicted by clinicians. However, the activation of related biochemical pathways and the cells acting on them can be controlled and prevented from developing the disease. Secondary brain injury can further aggravate brain injury, mainly through increased excitatory neurotransmitter activity, release of inflammatory cytokines and production of reactive oxygen species (ROS). Therefore, the control of inflammatory response is of great significance for the disease control and prognosis of brain injury. It is hoped that we can better understand the progress of inflammatory response of brain injury and increase more effective treatment methods for brain injury.