多囊卵巢综合征与同型半胱氨酸的研究新进展

New Advances of Polycystic Ovary Syndrome and Homocysteine

多囊卵巢综合征(PCOS)是育龄期妇女常见的内分泌紊乱疾病之一,除去本身固有的多囊样卵巢、高雄激素血症及排卵功能障碍的特点之外,常伴随肥胖、2型糖尿病和血脂代谢异常等。随着生活环境的改变,PCOS发病率呈上升趋势。如果PCOS病情一直没有好转,不但危害到病人的生殖健康,而且也会危害病人身体的保健。同型半胱氨酸(HCY)是一种在蛋氨酸循环过程中产生的含硫氨基酸,最近有研究声称高同型半胱氨酸血症增加了PCOS的发生、发展及不良预后风险,现就国内外这方面的研究进展做一综述。

Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women of childbearing age. In addition to the inherent characteristics of polycystic ovary, hyperandrogenemia and ovulation dysfunction, PCOS is often accompanied by obesity, type 2 dia-betes and dyslipidemia. With the change of living environment, the incidence of PCOS is increasing. If the condition of PCOS does not improve, it will not only harm the patient’s reproductive health, but also harm the patient’s health care. Homocysteine (HCY) is a sulfur-containing amino acid produced during the methionine cycle. Recently, it has been claimed that hyper-homocysteine increases the occurrence, development and adverse prognosis risk of PCOS. This paper reviews the research progress in this area at home and abroad.