年龄相关性疾病中免疫功能及炎症因子的变化研究

Study on the Changes of Adaptive Immune Function and Inflammatory Factors in Age-Related Diseases

目的:探讨年龄相关性疾病对免疫功能以及炎症因子水平影响的临床意义。方法:回顾性分析年龄相关性疾病患者192例以及对照组80例,根据不同疾病分为高血压组、糖尿病组、高血压合并糖尿病组、高血压或糖尿病合并急性脑梗死组,根据年龄各组进行亚组分析,分为年老组、年轻组,统计分析各组间淋巴细胞亚群和炎症因子的变化情况。结果:1) CD3-CD56+(NK)%、CD8+(Ts)%、CD4+/CD8+(Th/Ts)、IL-6在高血压或糖尿病合并脑梗死组显著升高;CD3-CD56+(NK)%、IL-6在高血压合并糖尿病组中显著升高,但CD4+/CD8+(Th/Ts)显著降低。2) 除糖尿病组外,各组中年老组较年轻组CD4+/CD8+(Th/Ts)降低;除高血压组外,各组年老组较年轻组CD19+(B)%降低;所有分组中老年组较年轻组CD3-CD56(NK)%、IL-6均升高。结论:合并年龄相关性疾病数量越多免疫功能降低越显著;当慢性年龄相关性疾病出现急性病变如急性脑梗死时,免疫系统功能激活、促炎反应增强;年龄在年龄相关性疾病的免疫功能下降和炎症水平的升高中具有促进作用。

Objective: To explore the clinical significance of the effect of age-related diseases on immune func-tion and inflammatory factors. Methods: 192 patients with age-related diseases and 80 patients in the control group were divided into hypertension group, diabetes mellitus group, hypertension complicated with diabetes group, hypertension or diabetes mellitus complicated with acute cere-bral infarction group according to different diseases. The patients were divided into old group and young group, and the changes of lymphocyte subsets and inflammatory factors were statistically analyzed. Results: 1) CD3-CD56+(NK)%, CD8+(Ts)%, CD4+/CD8+(Th/Ts), IL-6 increased significant-ly in patients with hypertension or diabetes mellitus complicated with cerebral infarction;CD3-CD56+(NK)%, IL-6 was significantly increased in hypertension complicated with diabetes, but CD4+/CD8+(Th/Ts) was significantly decreased. 2) Except for diabetes group, CD4+/CD8+(Th/Ts) in middle-aged group was lower than that in young group, CD19+(B)% in old group was lower than that in young group except hypertension group, and CD3-CD56 (NK)% and IL-6 in all groups were higher than those in young group. Conclusion: The more the number of age-related diseases, the more significant the decrease of immune function;When chronic age-related diseases appear acute lesions such as acute cerebral infarction, the immune system function is activated and the pro-inflammatory response is enhanced;Age plays a promoting role in the decline of immune func-tion of age-related diseases and the promotion of inflammatory level.