COPD患者诱导痰中IL-6、IL-8水平与炎症表型的相关性研究

Study on the Correlation between IL-6 and IL-8 Levels in Induced Sputum of COPD Patients and Inflammatory Phenotypes

目的:探讨慢性阻塞性肺疾病(慢阻肺,Chronic obstructive pulmonary disease,COPD)患者诱导痰中白介素-6 (interleukin-6, IL-6)、白介素-8 (interleukin-8, IL-8)与炎症表型的相关性,为COPD患者精准治疗提供理论依据及监测指标。方法:选取2019年12月至2020年12月山西医科大学附属汾阳医院30例慢性阻塞性肺疾病急性加重期患者(Acute exacerbation of chronic obstructive pulmonary disease, AECOPD)和30例慢性阻塞性肺疾病稳定期患者(Stable stage of chronic obstructive pulmo-nary disease, SCOPD),所选患者均行肺功能、诱导痰检查,分析诱导痰中IL-6、IL-8水平与COPD患者GOLD分级(又称肺功能分级)及炎症表型的关系。结果:AECOPD患者诱导痰中IL-6、IL-8水平明显高于SCOPD患者(P 嗜酸性粒细胞表型。结论:COPD患者诱导痰中IL-6、IL-8水平与慢阻肺患者急性加重相关,与GOLD分级呈正相关,在嗜酸性粒细胞表型中较非嗜酸性粒细胞表型中表达低。

Objective: To explore the correlation between induced sputum interleukin-6 (IL-6) and interleu-kin-8 (IL-8) and inflammatory phenotypes in patients with chronic obstructive pulmonary disease (COPD), so as to provide theoretical basis and monitoring indicators for precision therapy of COPD patients. Methods: To choose between December 2019 and December 2020 in Fenyang Hospital Af-filiated to Shanxi Medical University 30 cases of acute exacerbation of chronic obstructive pulmo-nary disease (AECOPD) and 30 cases of patients with stable stage of chronic obstructive pulmonary disease (SCOPD), lung function and induced sputum examinations were performed in all selected patients to analyze the relationship between IL-6 and IL-8 levels of induced sputum and GOLD grading (pulmonary function classification) and inflammatory phenotypes in COPD patients. Results: The IL-6 and IL-8 levels in the induced sputum of patients with AECOPD were significantly higher than those of patients with SCOPD (P eosinophilic phenotype. Conclusion: Levels of IL-6 and IL-8 in induced spu-tum of COPD patients correlated with acute exacerbations in COPD patients, positively correlated with gold grade, and have lower expression in the eosinophilic phenotype than in the non eosino-philic phenotype.