特发性肺纤维化与肺癌的共同致病机制

The Co-Pathogenesis of Idiopathic Pulmonary Fibrosis and Lung Cancer

在特发性肺纤维化(idiopathic pulmonary fibrosis, IPF)病程进展中,患者并发肺癌的概率明显偏高,且严重威胁患者生命健康,而IPF合并肺癌在肿瘤表现、临床诊断和治疗方面均有不同于单纯肺癌患者的特点。大量的流行病学证据支持IPF和肺癌之间的联系。对IPF和肺癌患者的最佳管理需要了解这两种疾病共同的致病机制和分子途径。本文综述了目前关于肺纤维化发病机制的研究现状,并通过其分子机制总结了IPF和肺癌的共同通路。

In the progression of idiopathic pulmonary fibrosis (IPF), the probability of patients with lung can-cer is significantly higher, and seriously threatens the life and health of patients, while IPF with lung cancer has characteristics different from those of patients with lung cancer alone in tumor manifes-tations, clinical diagnosis and treatment. Substantial epidemiological evidence supports an associa-tion between IPF and lung cancer. Optimal management of patients with IPF and lung cancer re-quires an understanding of the common pathogenic mechanisms and molecular pathways of both diseases. This paper reviews the current research on the pathogenesis of pulmonary fibrosis, and summarizes the common pathway of IPF and lung cancer through its molecular mechanism.