幽门螺旋杆菌感染与胃癌发病及防治相关性进展

Progress in the Correlation between Helicobacter pylori Infection and the Incidence and Prevention of Gastric Cancer

幽门螺旋杆菌进入机体后特异性地定植于胃黏膜表面,很难自行清除,其可以导致胃黏膜发生慢性活动性炎症,在此基础上还会发展成消化性溃疡、胃癌等。我国是胃癌的高发国家,发病率和死亡率均较高,其发生与感染、环境、遗传等多种因素有关。根除幽门螺旋杆菌可以有效降低胃癌的发病率。本文从发病及防治的角度就幽门螺旋杆菌与胃癌的相关性进展作一系统性综述。

After entering the body, H. pylori colonizes the gastric mucosa epithelium, which is difficult to re-move by itself. It can lead to active inflammation of gastric mucosa, and on this basis, it can also de-velop into peptic ulcer and gastric cancer. China is a country with high incidence of gastric cancer, with high morbidity and mortality, which is related to infection, environment, genetics and other factors. Eradication of Helicobacter pylori can effectively reduce the incidence of gastric cancer. In this paper, the progress of the correlation between Helicobacter pylori and gastric cancer was re-viewed systematically from the angle of pathogenesis, prevention and treatment.