摘要
2型糖尿病(Type 2 diabetes mellitus ,T2DM)仍然是威胁全人类健康及造成人们经济负担的最主要问题之一,其患病率和发病率呈逐渐增加的趋势。同时糖尿病也是导致失明、肾衰竭、心脏病发作、中风和下肢截肢的主要原因,其临床特征是高血糖、胰岛素抵抗(IR)和胰岛β细胞功能衰竭。在过去几年里,大量研究强调了肠道微生物群失调与T2DM及其并发症之间错综复杂的关系,迄今为止,该领域的已知文献暗示了肠道菌群在糖尿病微血管并发症的发生和演变中具有重要作用。在这篇综述中,我们讨论了肠道菌群与已知的糖尿病微血管并发症(视网膜病变、神经病变和肾病)之间的最新知识及其在糖尿病管理中的应用。
Type 2 diabetes mellitus (T2DM) is still one of the most important problems threatening human health and economic burden. The prevalence and incidence rate of disease is increasing. Diabetes is also the leading cause of blindness, renal failure, heart attack, stroke and lower limb amputation. Its clinical features are hyperglycemia, insulin resistance (IR) and pancreatic β cell failure. In the past few years, numerous studies have highlighted the perplexing relationship between intestinal microbiota imbalance and T2DM and its complications. So far, the known literature in this field suggests that intestinal flora plays an important role in the occurrence and evolution of diabetic microangiopathy. In this review, we discussed the latest knowledge of intestinal flora and known diabetic microvascular complications (retinopathy, neuropathy and nephropathy) and their appli-cation in diabetes management.
出处
《临床医学进展》
2022年第6期5299-5303,共5页
Advances in Clinical Medicine
