MicroRNA-155与结核分枝杆菌感染的相关研究进展

Research Progress on MicroRNA-155 Associated with Mycobacterium tuberculosis Infection

结核病是人类面对的主要慢性传染病之一,在诊断和治疗方面仍充满挑战。微小RNA (microRNA, miRNA)是一类在转录后水平调节基因表达的非编码RNA分子。大量研究表明,miR-155作为一个多功能miRNA,和结核病发生发展密切相关,在结核感染后的凋亡、自噬、细胞极化等活动中发挥免疫调节作用。有可能成为新的诊断标记物和治疗靶点。

Tuberculosis remains one of the major chronic infectious diseases faced by humankind, and it is still full of challenges in diagnosis and treatment. MicroRNAs (miRNAs) are a class of noncoding RNA molecules that regulate gene expression at the post transcriptional level. A large number of studies have demonstrated that miR-155, as a multifunctional miRNA, is closely related to the occurrence and development of tuberculosis, and plays an immunomodulatory role in apoptosis, autophagy, cell polarization and other activities after infection. It may become a new diagnostic marker and therapeutic target.