TRPA1/TRPV1通道参与慢性咳嗽的作用机制

Mechanism of TRPA1/TRPV1 Pathway Involved in Chronic Cough

慢性咳嗽是呼吸道疾病的常见症状之一,发病率高,病因繁杂,其发病机制尚未完全阐述。随着对咳嗽发病机制研究的增加,目前认为气道神经源性炎症引起的咳嗽敏感性增加是其重要的病理生理机制。瞬时受体电位(Transient receptor potential channel, TRP)通道广泛分布于人体各组织和器官,在呼吸道感觉神经纤维和非神经细胞中均广泛表达,其通过气道感觉神经元导致咳嗽反射的机制探讨成为当前研究的热点之一。本文就参与咳嗽反射过程的TRPA1/TRPV1通道在慢性咳嗽发病机理中的研究进展作一综述,以期为慢性咳嗽的深入研究及治疗的潜在药物靶点提供新思路。

Chronic cough is one of the common symptoms of respiratory diseases, with high incidence and complex etiology, and its pathogenesis has not been fully elaborated. With the increase in research on the pathogenesis of cough, it is currently considered that the increase in cough sensitivity caused by air canal neurogenic inflammation is an important pathophysiological mechanism. Instantane-ous receptor potential channels are widely distributed in various tissues and organs of the human body, widely expressed in respiratory sensory nerve fibers and non-nerve cells, and the mechanism of cough reflex caused by airway sensory neurons has become one of the hot spots in the current research. In this paper, the research progress of TRPA1/TRPV1 pathway involved in the cough re-flex process in the pathogenesis of chronic cough is reviewed, with a view to providing new ideas for the in-depth study and treatment of chronic cough.