肺腺癌卵巢转移1例并文献复习

A Case of Ovarian Metastasis from Adenocarcinoma of the Lung and Literature Review

目的:探讨肺腺癌卵巢转移的诊断及治疗,以期提高对该疾病的认识。方法:对1例肺腺癌引起卵巢患者的病例资料及相关文献进行回顾性分析。结果:肺腺癌引起的卵巢转移较为罕见,由于其缺乏典型的临床病例特征,术前诊断较困难。免疫组化可以作为评估肿瘤的重要辅助成分。结合使用NapsinA和TTF-1增加敏感性和特异性识别肺起源的转移性腺癌。全身治疗是转移性肺癌的标准治疗方法。结论:肺腺癌引起卵巢转移发病机制不明,临床表现无明显特异性。病理学检查为诊断的金标准。治疗方法主要为全身治疗,基于相关研究报道,肿瘤细胞减灭术可能是伴有卵巢转移的肺癌患者的很好的选择。

Objective: To explore the diagnosis and treatment of ovarian metastases in lung adenocarcinoma with a view to raising awareness of the disease. Methods: A retrospective analysis of the case data and related literature of a patient with ovarian disease caused by lung adenocarcinoma was con-ducted. Results: Ovarian metastases from lung adenocarcinoma are rare and preoperative, and di-agnosis is difficult due to its lack of typical clinical case features. Immunohistochemistry can be used as an important adjunct component in the evaluation of tumors. The combination of NapsinA and TTF-1 increases sensitivity and specificity in identifying metastatic adenocarcinoma of lung origin. Systemic therapy is the standard treatment for metastatic lung cancer. Conclusions: The pathogenesis of ovarian metastasis caused by lung adenocarcinoma is unknown, and the clinical manifestations are not obviously specific. Pathological examination is the gold standard for diagno-sis. Systemic therapy is the mainstay of treatment. Based on relevant research reports, debulking surgery may be a good choice for lung cancer patients with ovarian metastasis.