百日咳发病机制及合并感染机制研究进展

Research Progress on the Pathogenesis of Pertussis and Its Co-Infection

近年来百日咳发病有复燃趋势,儿童尤其是婴幼儿患百日咳后,一方面导致剧烈痉挛性咳嗽,同时患儿易合并其他病原体感染,造成病程迁延不愈,对健康造成很大危害,严重者甚至导致患儿死亡。百日咳发病机制以及患儿患百日咳后容易合并其他病原感染的确切原因尚未完全明确。本文就百日咳发病机制研究进展及百日咳患儿合并其他感染可能机制相关研究文献进行综述。

In recent years, the incidence of pertussis has a resurgence trend. Whooping cough in children, es-pecially infants, causes severe spasmodic cough, at the same time, children are easy to be infected by other pathogens, resulting in prolonged course of disease, even lead to death of children in seri-ous cases. Whooping cough pathogenesis and children with pertussis after the merger easily the exact cause of infection with other pathogens is not yet fully clear. The research on the pathogenesis of pertussis and the infection after suffering from pertussis is gradually increasing. However, there is still a lack of summary review reports, this paper summarizes the review.