残余胆固醇与血液透析患者血脂异常的现况

Remnant Cholesterol and Status of Dyslipidemia in Hemodialysis Patients

血液透析(HD)已成为大多数终末期肾病患者偏向选择的肾脏替代方式,心血管疾病(CVD)是其主要死亡原因。脂代谢紊乱是CVD和终末期肾病(ESRD)共同进展的机制。越来越多的证据表明,即使当低密度脂蛋白控制到最佳水平,残余胆固醇(RC)仍从流行病学及遗传学等方面被证明在预测ASCVD的发生中起着重要作用。现就HD患者血脂紊乱的特点及RC的定义、测量、机制、相关研究进展等进行总结。

Hemodialysis (HD) has become the preferred renal replacement for most patients with end-stage renal disease, and cardiovascular disease (CVD) is the leading cause of death. Dyslipidemia is a mechanism for the co-progression of CVD and end-stage renal disease (ESRD). There is increasing evidence that even when low-density lipoprotein is controlled to optimal levels, remnant cholester-ol (RC) is still proven to play an important role in predicting the occurrence of ASCVD from the as-pects of pathogenic mechanism, epidemiology and genetics. This article summarizes the character-istics of dyslipidemia in HD patients and the definition, measurement, mechanism, and related re-search progress of RC.