摘要
过氧化物酶体增殖物激活受体(Peroxisome Proliferation Activated Receptors, PPARs)属于核激素受体超家族成员,其三个亚型包括:PPAR-α、PPAR β/δ及PPAR-γ,它们各自都有其相应的配体、靶基因及生物学功能。巨噬细胞是机体免疫系统中的重要组成部分,同时介导了适应性免疫应答和非特异性免疫应答过程,具有吞噬功能、进行抗原提呈、分泌促炎或抗炎等细胞因子的功能。因此,巨噬细胞在防御、炎症、修复和代谢等生理过程中发挥着重要作用,也是维持体内平衡的关键因素。巨噬细胞主要分为M1、M2两个亚群,M1/M2的动态平衡对维持者机体内环境的稳态起到重要作用。PPARs则在转录调控巨噬细胞极化中扮演着重要角色。本文将系统阐述PPARs对巨噬细胞极化调控的影响以其在相关寄生虫病中的作用,从而为干预PPARs靶点调控巨噬细胞极化治疗有关寄生虫病提供治疗策略,也为有关寄生虫病的药物治疗提供新的靶点。
Peroxisome proliferation-activated receptors (PPARs) are a family of adopted orphan nuclear re-ceptors involved in lipid metabolism and inflammation, including three isoforms: PPAR-α, PPAR β/δ, and PPAR-γ, each of which has distinct ligands, target genes and biological functions. Macro-phages are an important part of the body’s immune system, mediating the adaptive immune re-sponse and non-specific immune response processes, and have the function of phagocytosis for an-tigen presentation and secretion of pro-inflammatory or anti-inflammatory cytokines. Therefore, macrophages play an important role in physiological processes of defense, inflammation, repair and metabolism, and are also a key factor in homeostatic maintenance. Macrophages are high plasticity, and there are various subtypes after macrophage polarization. M1 (classically activated macro-phage, CAMs) and M2 (alternatively activated macrophage, AAMs) phenotype are the two extremes of macrophage polarization, which jointly regulates the homeostasis of its internal environment. In this review, the effects of PPARs on the regulation of macrophage polarization and its role in related parasitic diseases were systematically elaborated, so as to provide therapeutic strategies for the intervention of PPARs target in the regulation of macrophage polarization in the treatment of re-lated parasitic diseases, as well as new targets for the drug treatment of related parasitic diseases.
出处
《临床医学进展》
2022年第7期6282-6290,共9页
Advances in Clinical Medicine
