炎症性肠病的复发因素研究进展

Research Progress of Relapse Factors in Inflammatory Bowel Disease

炎症性肠病(inflammatory bowel disease, IBD)主要包括溃疡性结肠炎(ulcerative colitis, UC)和克罗恩病(Crohn disease, CD),是一种主要累及胃肠道的非特异性、慢性、复发性、进展性的炎症性疾病。近年来在世界范围内,发病率逐渐上升,成为消化科的常见病。发病人群以青壮年为主,主要表现为持续性的腹泻、腹痛、呕吐、血便、粘液便等,具有病程长,容易复发等特点。虽然生物制剂治疗取得了较好的疗效,但复发率高、复发的确切因素仍难以肯定。近年来研究发现,IBD的复发与病程及病变范围、感染、饮食、生物标志、疾病治疗、生活方式、心理、基因等因素密切相关,现对于IBD的复发因素进行综述,应针对影响因素采取相应的措施,有利于预防IBD的复发,改善患者的预后提供帮助。

Inflammatory bowel disease (IBD), whose main forms includes ulcerative colitis (UC) and Crohn’s disease (CD), is a non-specific, chronic, recurrent and progressive inflammatory disease that pri-marily affects the gastrointestinal tract. In recent years, IBD has gradually become a common dis-ease in gastroenterology, with its incidence rising worldwide. This disease is mainly affecting young adults and is characterized by persistent diarrhoea, abdominal pain, vomiting, bloody stools and mucous stools. Although biological agents have achieved good efficacy in the treatment of IBD, it is still hard to identify the causes for its high recurrence rate and specific factors for recurrence. Re-cently, it has been found that relapse of IBD is closely related to the duration and extent of the dis-ease, infection, diet, biomarkers, previous treatment methods, lifestyle, mental state, genes and other factors. A review of the relapse factors of IBD is presented in this paper, and appropriate measures should be taken to cope with the above influencing factors to prevent IBD recurrence and improve the prognosis of patients.