LINC00511调控miRNA促进癌症的进展

LINC00511 Regulates miRNAs to Promote Cancer Progression

癌症是全球第二大最常见的死亡原因,癌症的发生是由于改变细胞增殖、分化和死亡的正常程序的关键基因突变的积累,研究致癌基因将有助于寻找癌症早期诊断及治疗的新途径。长期以来,lncRNA被认为是RNA聚合酶转录过程中形成的非功能性产物,随着医学技术的发展,lncRNA在生理和病理过程中发挥着重要作用,受到了广泛的关注,lncRNA被认为是调控肿瘤微环境的关键因子,是肿瘤治疗的靶点。LINC00511是一种新发现的lncRNA,并作为致癌基因在癌症中有上调,具有调控mRNAs的功能并参与调控癌症的增殖、侵袭和转移并导致患者的预后不良。

Cancer is the second most common causes of death in the world. Cancer occurs due to the accumula-tion of key gene mutations that change the normal process of cell proliferation, differentiation and death. Research on oncogenes will help find new ways of early diagnosis and treatment of cancer. For a long time, lncRNA has been regarded as a non-functional product formed during the tran-scription process of RNA polymerase. With the development of medical technology, lncRNA plays an important role in the physiological and pathological processes, and has received extensive atten-tion. lncRNA is considered to be a regulation. The key factor of tumor microenvironment is the tar-get of tumor treatment. LINC00511 is a newly discovered lncRNA and is up-regulated as an onco-gene in cancer. It may have the function of regulating mRNAs and participate in the regulation of cancer proliferation, invasion and metastasis and lead to poor prognosis of patients.