儿童传染性单核细胞增多症诊断的研究进展

Advances in the Diagnosis of Infectious Mononucleosis in Children

传染性单核细胞增多症(infectious mononucleosis, IM)是儿童常见急性自限性传染病,由EB病毒(Epstein-Barr virus, EBV)感染所致,临床典型症状为发热、咽喉炎、肝脾和淋巴结肿大,因其临床表现多样性以及不典型症状的增加,使此类疾病早期诊断难度升高,易造成误诊。为提高IM的确诊率,降低漏诊、误诊率,本文主要从病原学、发病机制、临床症状、实验室特点、诊断、治疗的研究进展,综述目前儿童传染性单核细胞增多症诊断的研究进展。

Infectious mononucleosis (IM) is a common acute self-limited infectious disease in children, which is caused by Epstein-Barr virus (EBV) infection. The typical clinical symptoms are fever, laryngitis, hepatosplenomegaly and lymph node enlargement. Because of the diversity of clinical manifesta-tions and the increase of atypical symptoms, the early diagnosis of this disease is difficult and easy to cause misdiagnosis. In order to improve the diagnosis rate of IM and reduce the rate of missed diagnosis and misdiagnosis, this article reviews the current research progress in the diagnosis of pediatric infectious mononucleosis from the perspectives of etiology, pathogenesis, clinical symp-toms, laboratory characteristics, diagnosis and treatment.