Npn2与其细胞因子VEGF、Sema3F的相关性

Correlation between Npn2 and Its Cytokines VEGF and Sema3F

血管内皮生长因子(vascular endothelial growth factor, VEGF)是一个家族,包括VEGF-A、VEGF-B、VEGF-C、VEGF-D、VEGF-E和胎盘生长因子。神经毡蛋白(Neuropilin, Npn)是一类分子量为120~140 KD的I型跨膜蛋白,可参与机体的一系列生理和病理过程。信号素蛋白(Semaphorin Proteins, SIMAs)最初被认为是神经发育过程中排斥和吸引的神经引导线索。Npn2与其细胞因子VEGF、Sema3F参与多种中枢神经系统疾病,本文主要探讨其三者各自的功能及其关系。

Vascular endothelial growth factor (vascular endothelial growth factor, VEGF) is a family that in-cludes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and placental growth factor. Neurofelt protein (Neuropilin, Npn) is a type I transmembrane protein with molecular weight of 120~140 KD, which can participate in a series of physiological and pathological processes. The signaling proteins (Sem-aphorin Proteins, SIMAs) were originally thought to be neuro-guiding cues of rejection and attrac-tion during neural development. Npn2 and its cytokines VEGF and Sema3F are involved in a variety of central nervous system diseases.