血管内皮生长因子家族在冠心病发生发展中的作用及研究现状

The Role of Vascular Endothelial Growth Factor Family in the Development of Coronary Heart Disease

血管内皮生长因子(Vascular endothelial growth factor, VEGF)是一类发现较早且作用广泛的细胞因子,作为一种促血管内皮细胞生长的细胞因子,VEGF (Vascular endothelial growth factor, VEGF)可增加血管通透性,促进血管内皮细胞增生及血管形成,是血管和淋巴管的调节因子。过去有关VEGF (Vascular endothelial growth factor, VEGF)的研究主要集中在肿瘤和眼科领域。近年来,随着心血管领域研究的进一步深入,越来越多的研究发现,它参与了动脉粥样硬化和其他心血管疾病的发展,尤其是在冠状动脉粥样硬化性心脏病的发生发展过程中发挥着重要的作用。目前的研究发现,在人类中,VEGF家族(Vascular endothelial growth factor, VEGF)由5个独立的基因产物组成:调节血管生长的VEGF-A (Vascular endothelial growth factor A, VEGF-A)、VEGF-B (Vascular endothelial growth factor B, VEGF-B)、胎盘生长因子(placental growth factor, PlGF)以及调节淋巴管生成的VEGF-C (Vascular endothelial growth factor C, VEGF-C)和VEGF-D (Vascular endothelial growth factor D, VEGF-D)。它们在冠心病发生发展过程中展现出各自的抗炎及促炎作用。本文将对血管内皮生长因子家族在冠心病发生发展中的作用及研究现状进行综述,为以后的基础研究或者临床实践提供一些参考。

Vascular endothelial growth factor (VEGF) is a kind of cytokines discovered earlier and widely used. As a cytokine that promotes the growth of vascular endothelial cells, VEGF can increase vascular permeability, promote vascular endothelial cell proliferation and angiogenesis, and is a regulator of blood vessels and lymphatic vessels. In the past, studies on VEGF mainly focused on the fields of tu-mor and ophthalmology. In recent years, with the further research in the field of cardiovascular, more and more studies have found that it is involved in the development of atherosclerosis and other cardiovascular diseases, especially in the occurrence and development of coronary athero-sclerotic heart disease plays an important role. Current studies have found that in humans, the VEGF family consists of five independent genetic products: VEGF-A, VEGF-B, placental growth factor regulating vascular growth, and VEGF-C and VEGF-D regulating lymphangiogenesis. They show their anti-inflammatory and pro-inflammatory effects in the development of coronary heart disease. This article will review the role and research status of vascular endothelial growth factor family in the development of coronary heart disease, and provide some reference for future basic research or clinical practice.