维生素D在中枢神经系统中的作用及意义

The Role and Significance of Vitamin D in the Neonatal Nervous System

近年来,维生素D的研究已有不少报道,进展很快,与此同时,维生素D与大脑的功能发育之间的关系也受到人们极大的重视。维生素D是具有类固醇激素功能的一类化学物质,可参与神经细胞增殖、分化、凋亡等过程的调控。研究显示维生素D不但对多种成人神经病变有重要影响,对新生儿神经元发育及修剪同样具有至关重要的影响。维生素D可以作为抗增殖剂存在于多种组织,其中发育性维生素D (DVD)不足已经被证明可以改变大脑的结构发育及功能。维生素D缺乏可能增加脑损伤风险,且最新临床研究证实缺氧缺血性脑损伤的新生儿通常存在维生素D缺乏,补充维生素D则可能改善脑损伤的结局。

In recent years, there have been many reports on vitamin D research, and the progress is rapid, and at the same time, the relationship between vitamin D and the functional development of the brain has also received considerable attention. Vitamin D is a kind of chemicals with steroid hormone function, which can participate in the regulation of nerve cell proliferation, differentiation, apopto-sis and other processes. Studies have shown that vitamin D can not only have an important impact on a variety of adult neuropathy, but also on neonatal neuronal development and pruning. Vitamin D can exist as an antiproliferator in a variety of tissues, and developmental vitamin D (DVD) defi-ciency has been shown to alter the structural development and function of the brain. Vitamin D de-ficiency may increase the risk of brain injury, and the latest clinical studies have confirmed that neonates with hypoxic and ischemic brain injury usually have vitamin D deficiency, and vitamin D supplementation may improve the outcome of brain injury.