基于SEER数据库乳腺腺样囊性癌临床病理特征及预后分析

Clinicopathological Features and Prognosis of Adenoid Cystic Carcinoma of the Breast Based on SEER Database

目的:探讨乳腺腺样囊性癌患者的临床病理特征、预后及相关影响因素。方法:从SEER数据库中提取2010年至2016年诊断为乳腺腺样囊性癌的148例女性患者的病例资料,回顾性分析其临床病理特征、生存情况及预后影响因素。结果:乳腺腺样囊性癌患者148例中,107例(72.3%)为三阴性乳腺癌,77例(52.0%)为组织学分级I级,80例(54.1%)为T1期,143例(96.6%)为N0期,148例(100.0%)为M0期,148例(100.0%)接受手术治疗,89例(60.1%)接受放疗,133例(89.9%)未进行化疗。单因素分析显示:年龄、原发灶部位、组织学分级、N分期、化疗与患者预后有关(P < 0.05)。多因素COX回归分析显示:年龄、组织学分级是影响病人预后的独立危险因素(P < 0.05)。结论:影响乳腺腺样囊性癌患者预后的独立危险因素是年龄、分级。放疗和化疗对乳腺腺样囊性癌患者的总生存率是否有益有待进一步研究探讨。

Objective: To investigate the clinicopathological features, prognosis and related influencing factors of patients with adenoid cystic carcinoma of the breast. Methods: Case data of 148 female patients diagnosed with adenoid cystic carcinoma of the breast from 2010 to 2016 were extracted from the SEER database, the clinicopathological characteristics, survival and prognostic factors were retro-spectively analyzed. Results: Among 148 patients with adenoid cystic carcinoma of the breast, 107 cases (72.3%) were triple negative breast cancer, 77 cases (52.0%) were histological grade I, 80 cases (54.1%) were T1 stage, 143 cases (96.6%) were N0 stage, 148 cases (100.0%) was M0 stage, 148 cases (100.0%) received surgery, 89 cases (60.1%) received radiotherapy, and 133 cases (89.9%) did not receive chemotherapy. Univariate analysis showed that age, primary tumor site, histological grade, N stage and chemotherapy were related to the prognosis of patients (P < 0.05). Multivariate COX regression analysis showed that age and histological grade were independent risk factors affecting the prognosis of patients (P < 0.05). Conclusion: The independent risk factors af-fecting the prognosis of patients with adenoid cystic carcinoma of the breast are age and grade. Whether radiotherapy and chemotherapy are beneficial to the overall survival of patients with ad-enoid cystic carcinoma of the breast remains to be further investigated.