CD4⁺ T细胞能量代谢在神经系统自身免疫性疾病中的研究进展

Research Progress of CD4⁺ T Cell Energy Metabolism in Autoimmune Diseases of the Nervous System

CD4+ T细胞在机体免疫系统中具有重要作用,根据活化后的功能不同可分为辅助性T细胞(T helper cells, Th)和调节性T细胞(regulatory T cells, Treg),Th包括Th1、Th2、Th9、Th17、Th22等亚群。CD4+ T细胞在发育、激活和介导免疫应答等过程中均会进行代谢重编程,以满足其对应的能量需求,CD4+ T细胞能量代谢异常会导致机体免疫功能紊乱,在自身免疫性疾病中发挥重要作用。本文主要对CD4+ T细胞亚群能量代谢异常与自身免疫性疾病相关研究进展进行综述。

CD4+ T cells play an important role in the body’s immune system. According to different functions after activation, they can be divided into helper T cells (T helper cells, Th) and regulatory T cells (Treg). Th includes Th1, Th2 , Th9, Th17, Th22 and other subgroups. CD4+ T cells undergo metabolic reprogramming during development, activation, and mediating immune responses to meet their corresponding energy needs. Abnormal energy metabolism of CD4+ T cells can lead to immune dys-function and play an important role in autoimmune diseases. This article mainly reviews the re-search progress of abnormal energy metabolism of CD4+ T cell subsets and autoimmune diseases.