中国矮小儿童和青少年尿酸与高密度脂蛋白胆固醇之比和收缩压的关系

Association between the Uric Acid to High Density Lipoprotein Cholesterol Ratio and Systolic Pressure in Chinese Short Stature Children and Adolescents

目的:本研究旨在探讨身材矮小的儿童和青少年尿酸与高密度脂蛋白胆固醇比值(UHR)和收缩压(SBP)的关系。方法:在这项横断面分析中,选择了2013年3月1日至2021年12月31日在济宁医学院附属医院内分泌科接受评估的1510名矮小症儿童和青少年的临床数据,收集其基线临床资料,分析UHR与SBP之间的关系。结果:单因素分析结果显示,UHR与SBP呈正相关(β 0.75, P < 0.0001)。此外,在调整了可能的混杂因素后,通过平滑曲线拟合发现UHR和SBP之间存在非线性关系,经多元分段线性回归分析,拐点为6.33%。当UHR大于6.33%时,SBP随UHR升高而增加(β 0.33, 95% CI 0.12, 0.54;P = 0.0019),然而,当UHR小于6.33% (P = 0.0736)时,我们没有观察到显著的相关性。结论:我们的研究发现,在身材矮小的儿童和青少年中,UHR和SBP之间存在非线性关系,并表明当UHR达到拐点时,SBP水平与UHR的升高呈正相关。这一发现表明UHR可能与SBP水平的调节有关,这种关系值得进一步研究。

Objective: This study aims to investigate the relationship between the uric acid to high density lip-oprotein cholesterol ratio (UHR) and systolic blood pressure (SBP) in children and adolescents with short stature. Methods: In this cross-sectional analysis, clinical data of 1510 children and adoles-cents were evaluated in the Department of Endocrinology, Affiliated Hospital of Jining Medical Col-lege from 1 March 2013 to 31 December 2021, their baseline clinical data were collected and the relationship between UHR and SBP was analyzed. Results: In the univariate analysis, UHR was posi-tively associated with SBP (β 0.75, P < 0.0001). Furthermore, after adjusting for possible confound-ers, a non-linear relationship between UHR and SBP was found by smoothing curve fitting, and the inflection point was 6.33% by multiple piecewise linear regression analysis. When the UHR is greater than 6.33%, SBP increases with increasing UHR (β 0.33, 95% CI 0.12, 0.54;P = 0.0019). However, we did not observe a significant correlation when the UHR was less than 6.33% (P = 0.0736). Conclusions: Our study found a nonlinear relationship between UHR and SBP in short stat-ure children and adolescents, and showed that SBP levels are positively associated with increased UHR when UHR reaches an inflection point. This finding suggests that the UHR may be related to the regulation of SBP levels, and this relationship warrants further investigation.