PGK1在肿瘤中的研究进展

Research Progress of PGK1 in Tumor

磷酸甘油激酶1 (PGK1)是糖酵解过程中产生ATP的第一个关键代谢酶,参与肿瘤的糖酵解途径。PGK1不仅可以作为一种代谢酶,影响肿瘤生长,也可以通过其非代谢酶功能影响肿瘤细胞的基因表达、能量代谢、分子调控等过程,进而介导肿瘤的生长、迁移和侵袭,加剧恶性癌细胞生物学特征。本文通过对PGK1的结构、功能及其与肿瘤的关系进行综述,阐明PGK1在肿瘤进展中的重要作用,为靶向PGK1进行药物开发提供理论基础。

Phosphoglycerate kinase 1 (PGK1) is the first key metabolic enzyme to produce ATP during glycoly-sis and is involved in the glycolysis pathway of tumors. PGK1 can not only affect tumor growth as a metabolic enzyme, but also affect gene expression, energy metabolism, molecular regulation and other processes of tumor cells through its non-metabolic enzyme function, thus mediating tumor growth, migration and invasion, and exacerbating the biological characteristics of malignant cancer cells. In this paper, the structure, function and relationship between PGK1 and tumor were re-viewed to clarify the important role of PGK1 in tumor progression and provide theoretical basis for drug development targeting PGK1.