肠道菌群与冠心病的相关关系研究

Study on the Relationship between Intestinal Flora and Coronary Heart Disease

人体内居住着大量的微生物,其中大部分位于胃肠道,人类的胃肠道中有着1013~1014种细菌(即肠道菌群),肠道菌群在人体形成一个庞大而复杂的微生态系统。在参与能量代谢、调节免疫、营养循环及人类健康和疾病方面发挥着重要的作用。人体肠道系统的变化会影响新陈代谢,并可能导致疾病的发生。近年来,国内外研究发现肠道菌群在心脑血管尤其与冠心病密切相关,一些研究已经确定了冠心病患者肠道微生物群组成和代谢的特征性变化。肠道菌群及代谢产物在冠心病诊断、治疗、预后方面也起着重要作用。或许在不久的将来,肠道菌群在疾病的诊断、治疗、预防等方面的作用将会对人类医学进步产生重要意义。此篇文章阐述了近年来的一些相关研究,为下一步研究肠道菌群与冠心病的关系及预防冠心病的发生、发展提供一些新思路、新想法。

There are a large number of microorganisms living in the human body, most of which are located in the gastrointestinal tract. There are 1013~1014 kinds of bacteria (intestinal flora) in the human gas-trointestinal tract. Intestinal floras form a huge and complex micro-ecosystem in the human body. It plays an important role in participating in energy metabolism, regulating immunity, nutrient cy-cling and human health and disease. Changes in the human gut system can affect metabolism and can lead to disease. In recent years, domestic and foreign studies have found that the gut microbiota is closely related to coronary heart disease, especially in the cardiovascular and cerebrovascular disease. Some studies have identified the characteristic changes in the composition and metabolism of the gut microbiota in patients with coronary heart disease. Intestinal flora and metabolites also play an important role in the diagnosis, treatment and prognosis of coronary heart disease. Perhaps in the near future, the role of gut microbiota in the diagnosis, treatment, and prevention of diseases will be of great significance to the progress of human medicine. This article describes some related research in recent years, and provides some new ideas for the next step to study the relationship between intestinal flora and coronary heart disease and to prevent the occurrence and develop-ment of coronary heart disease.