调节性T细胞作为抗癌治疗的潜在靶点

Regulatory T Cells as Potential Therapeutic Targets for Anticancer Therapy

免疫逃避是大多数人类恶性肿瘤的特征,并通过各种机制诱导。免疫抑制细胞,包括调节性T细胞(Regulatory T cells, Tregs)和髓源性抑制细胞(myeloid-derived suppressor cell, MDSCs),是帮助肿瘤逃避免疫监视的关键介质。此篇综述讨论了Treg在癌症进展中的作用、当前靶向Treg的治疗策略以及临床应用前景。

Immune evasion characterizes most human malignancies and is induced by various mechanisms. Immunosuppressor cells, including Regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), are key mediators that help tumors evade immune surveillance. This review discusses the role of Tregs in cancer progression, current Treg-targeting therapeutic strategies, and clinical pro-spects.