泛素特异性蛋白酶在头颈部鳞状细胞癌中的研究进展

Research Progress of Ubiquitin-Specific Pep-tidases in Head and Neck Squamous Cell Carcinoma

头颈部鳞状细胞癌(head and neck squamous cell carcinoma, HNSCC)是一种高度侵袭性和增殖性的肿瘤,其五年生存率较低,主要原因是对HNSCC的发病机制认识不清,缺乏有效的治疗手段。泛素特异性蛋白酶(ubiquitin-specific peptidases, USPs)是去泛素化酶家族的主要成员,能够识别特定蛋白质的泛素化信号,从而使靶蛋白去泛素化,进而参与细胞增殖、分化、凋亡和迁移等多种生物学功能。在这篇综述中,我们将对一些USPs在HNSCC发生发展中的作用进行阐述,为HNSCC的诊断和靶向治疗奠定基础。

Head and neck squamous cell carcinoma (HNSCC) is a highly invasive and proliferative tumor with a low five-year survival rate, mainly due to the poor understanding of the pathogenesis of HNSCC and the lack of effective treatment. The ubiquitin-specific peptidases (USPs) are the main member of the deubiquitinase family. The USPs involve in multiple biological processes including cell proliferation, differentiation, apoptosis and migration by specially recognizing and removing ubiquitin chain of target proteins. In this review, we will elaborate on the role of some USPs in tumorigenesis and progression of HNSCC, in order to lay the foundation for the diagnosis and targeted therapy of HNSCC.