组织工程支架应用于关节软骨修复的研究进展

Advances in the Application of Tissue Engineering Scaffolds for Articular Cartilage Repair

软骨损伤(cartilage damage)在骨科临床上是十分常见的疾病之一。由于关节软骨组织内既无神经也无血管供应,同时缺乏淋巴回流,使软骨自我修复十分有限。关节软骨的损伤可导致关节疼痛、畸形、关节活动功能受限进而发展为骨性关节炎。基于目前组织工程在充分利用支架材料、种子细胞、生长因子等方面表现出巨大潜能,组织工程技术为骨软骨再生修复取得了理想的成果。文章就近年来对组织工程支架关节软骨修复进行简单综述,报道如下。

Cartilage damage is a very common disease in orthopedic practice. However, the ability of cartilage to self-repair is limited due to the insufficiency of nerve and vascular supply as well as lymphatic flow. Injury to articular cartilage can lead to joint pain, deformity, limited joint movement and then to osteoarthritis. Based on the great potential of tissue engineering to make full use of scaffold ma-terials, seed cells, and growth factors, tissue engineering techniques have achieved desirable re-sults for osteochondral regeneration and repair. The article provides a brief review of literature in recent years on tissue engineering in articular cartilage repair, which is reported below.