摘要
下腰痛已成为一个全球关注的公共卫生问题,而椎间盘退行性变被公认为是引起下腰痛的主要原因之一。目前对下腰痛的治疗仅限于在减轻症状,而不能针对椎间盘内潜在的病理生理变化进行根本性治疗。PI3K/AKT通路的激活可以延缓椎间盘退变的进展。本文综述了PI3K/AKT信号通路的激活和负调控的最新研究进展,并着重介绍了不同的治疗方式通过PI3K/AKT信号通路对椎间盘退变产生的积极作用。相信在不久的将来,干预该信号通路有望成为一种有吸引力的治疗策略。
Low back pain has become a global public health problem, and intervertebral disc degeneration is recognized as one of the main causes of low back pain. At present, the treatment of low back pain is limited to relieving symptoms, but cannot fundamentally treat the underlying pathophysiological changes in intervertebral discs. The activation of PI3K/AKT pathway can delay the progression of intervertebral disc degeneration. This article reviews the latest research progress in the activation and negative regulation of PI3K/AKT signal pathway, and focuses on the positive effects of different treatments on intervertebral disc degeneration through PI3K/AKT signal pathway. It is believed that intervention in this signaling pathway is expected to become an attractive therapeutic strategy in the near future.
出处
《临床医学进展》
2022年第11期10075-10080,共6页
Advances in Clinical Medicine
