良性前列腺增生的药物治疗现状

Current Status of Drug Therapy for Benign Prostatic Hyperplasia

良性前列腺增生症是中老年男性中比较常见的一类排尿障碍类的疾病,主要临床表现是下尿路症状(LUTS),它包括尿等待、尿流不畅、排尿不全、尿潴留、尿失禁,以及刺激性症状尿频、尿急、夜尿和急迫性尿失禁等。它严重影响中老年的生活质量,现在主要的治疗方式是微创手术治疗、药物治疗。其中药物治疗是治疗前列腺增生不可或缺的一个部分,主要包括α受体阻滞剂、5-α还原酶抑制剂、M受体阻滞剂、磷酸二酯酶-5-抑制剂、β3激动剂、植物制剂、联合治疗及中医药。现在由于发病人群的年轻化以及病情的轻重程度使药物治疗逐渐成为了某些患者的首选治疗方式。

Benign prostatic hyperplasia (BPH) is a common urination disorder in middle-aged and elderly man. Its main clinical manifestation is lower urinary tract symptoms (LUTS), which include urinary wait-ing, dyspnea, dysuria, urinary retention, urinary incontinence, irritant symptoms such as frequent urination, urgent urination, nocturnal urination and urgent urinary incontinence. It seriously af-fects the quality of life of the middle-aged and elderly, and now the main treatment is minimally invasive surgery and drug therapy. Drug therapy is an indispensable part of the treatment of be-nign prostatic hyperplasia. It mainly includes α receptor blockers, 5-α reductase inhibitors, M re-ceptor blockers, phosphodiesterase-5-inhibitors, β3 agonists, plant preparations, combined therapy and traditional Chinese medicine. Now, due to the younger age of the disease and the severity of the disease, drug therapy has gradually become the first choice for some patients.